Description

Platinated 2'-Deoxyguanylyl-(3'--5')-3'-Deoxyguanosine is a specialized platinum-modified dinucleotide, a critical building block for advanced biochemical research and therapeutic development. This compound is essential for studying platinum-DNA interactions, which are fundamental to understanding the mechanisms of action for platinum-based anticancer drugs like cisplatin. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology research, structural biology, and the development of novel chemotherapeutic agents and targeted drug delivery systems.

Application

• Mechanistic Studies in Oncology: Serves as a model compound to investigate the binding kinetics, structural distortions, and repair mechanisms associated with platinum-DNA adducts, which are central to the efficacy and toxicity of platinum chemotherapeutics.
• Drug Discovery & Development: Used as a reference standard or a synthetic intermediate in the research and development of next-generation platinum-based anticancer drugs and combination therapies.
• Structural Biology & Biophysics: Employed in X-ray crystallography, NMR spectroscopy, and other analytical techniques to determine the three-dimensional structure of platinum-DNA complexes.
• Biochemical Assay Development: Acts as a substrate or inhibitor in enzymatic assays to study DNA polymerases, repair enzymes, and other proteins that interact with platinated DNA.
• Analytical Reference Standard: Provides a high-purity standard for the qualitative and quantitative analysis of platinum-nucleotide adducts in biological samples via HPLC, LC-MS, or other chromatographic methods.

Basic Information

Product Name	Platinated 2'-Deoxyguanylyl-(3'--5')-3'-Deoxyguanosine
CAS No.	97333-55-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Platinated d(GpG); cis-Platinum(II) d(GpG) adduct; Platinum-modified GG dinucleotide; cis-[Pt(NH3)2{d(GpG)-N7(1),-N7(2)}]; 2'-Deoxyguanylyl-(3'→5')-2'-deoxyguanosine, platinum complex; GG intrastrand crosslink; Platinum-DNA dinucleotide adduct
EINECS	Contact for details

Quality Control

Our Platinated 2'-Deoxyguanylyl-(3'--5')-3'-Deoxyguanosine is manufactured under stringent conditions to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and spectroscopic methods (e.g., UV, MS, NMR) for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment to maintain stability, as the compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.