Description

8-Benzyloxy-2'-Deoxy-D-Guanosine is a chemically modified nucleoside derivative, specifically a benzyl-protected analog of 2'-deoxyguanosine. This compound is a critical building block in oligonucleotide synthesis and pharmaceutical research, offering precise control over nucleic acid structure and function. It is primarily utilized by researchers and manufacturers in the fields of antiviral drug development, antisense oligonucleotide therapeutics, and biochemical research where high-purity, specialized nucleosides are required.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA and RNA strands.
• Antiviral & Anticancer Prodrug Development: Serves as an intermediate in the synthesis of nucleoside analog prodrugs targeting viral polymerases and cellular replication.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving polymerases, kinases, and other nucleic acid-metabolizing enzymes.
• Protecting Group Strategy: The benzyloxy group provides a stable protecting group for the guanine base during multi-step synthetic sequences.
• Labeled Compound Synthesis: A starting material for the preparation of isotopically labeled (e.g., 13C, 15N) nucleosides for metabolic tracing and NMR studies.
• Apitamer Development: Incorporated into SELEX libraries to create modified aptamers with enhanced binding affinity and nuclease resistance.

Basic Information

Product Name	8-Benzyloxy-2'-Deoxy-D-Guanosine
CAS No.	96964-90-8
Molecular Formula	C₁₇H₁₉N₅O₄
Molecular Weight	357.36 g/mol
Synonyms	8-Benzyloxy-2'-deoxyguanosine; 2'-Deoxy-8-benzyloxyguanosine; 8-O-Benzyl-2'-deoxyguanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-8-(phenylmethoxy)-1H-purin-6-one; 8-Bn-dG; dG(Bn)
EINECS	Contact for details

Quality Control

Our 8-Benzyloxy-2'-Deoxy-D-Guanosine is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.