Description

5'-o-Palmitoyl-5-Fluoro-2'-Deoxyuridine is a lipophilic prodrug derivative of the established antimetabolite 5-fluoro-2'-deoxyuridine (FdUrd). This chemical modification, specifically the esterification with palmitic acid at the 5'-position, is designed to enhance cellular uptake and improve the pharmacokinetic profile of the parent nucleoside. It is primarily utilized in advanced pharmaceutical research and development, particularly in oncology, for creating novel targeted therapies and drug delivery systems. This compound is critical for researchers and manufacturers focused on improving the efficacy and specificity of chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel nucleoside-based anticancer prodrugs.
• Oncology Research: Used in preclinical studies to investigate enhanced drug delivery mechanisms for 5-fluorouracil (5-FU) analogs.
• Lipid-Conjugate Development: Acts as a model compound for studying the impact of fatty acid conjugation on drug solubility, stability, and membrane permeability.
• Targeted Therapy Formulation: Employed in the development of liposomal or nanoparticle-based formulations for site-specific cancer treatment.
• Biochemical Tool: Utilized as a specialized reagent in enzymatic studies related to nucleoside metabolism and activation pathways.

Basic Information

Item	Details
Product Name	5'-o-Palmitoyl-5-Fluoro-2'-Deoxyuridine
CAS No.	96733-83-4
Molecular Formula	C25H41FN2O7
Molecular Weight	500.61 g/mol
Synonyms	5'-O-Palmitoyl-5-fluoro-2'-deoxyuridine; FdUrd-Palmitate; 5-Fluoro-2'-deoxyuridine 5'-palmitate; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-fluoro-2,4-dioxo-1H-pyrimidin-3-yl hexadecanoate; Palmitoyl-FdUrd; 5-Fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(palmitoyloxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our 5'-o-Palmitoyl-5-Fluoro-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.