Description

3-(Deoxyguanosin-N2-Yl)-4-Aminoquinoline 1-Oxide is a specialized nucleoside adduct compound of significant interest in biochemical and toxicological research. This compound matters as a critical reference standard for studying DNA damage and mutagenesis mechanisms, particularly those induced by heterocyclic aromatic amines. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and diagnostic companies focused on genetic toxicology, biomarker discovery, and the development of analytical methods for detecting carcinogen-DNA interactions.

Application

• Biomarker Research: Used as a certified reference material for the quantification of specific DNA adducts in biological samples, aiding in exposure assessment and biomonitoring studies.
• Toxicology & Mutagenesis Studies: Serves as a critical tool for investigating the metabolic activation, DNA binding, and repair pathways of quinoline-based carcinogens.
• Analytical Method Development: Employed as a high-purity standard for calibrating advanced analytical instruments like LC-MS/MS and HPLC in forensic and environmental analysis.
• Pharmaceutical Safety Assessment: Utilized in preclinical studies to understand potential genotoxic impurities and to validate safety screening protocols for new chemical entities.
• Academic Research: Fundamental research into the structural and functional consequences of specific DNA lesions on replication and transcription.

Basic Information

Product Name	3-(Deoxyguanosin-N2-Yl)-4-Aminoquinoline 1-Oxide
CAS No.	96681-97-9
Molecular Formula	C23H22N8O5
Molecular Weight	490.47 g/mol
Synonyms	N2-(3-Amino-1-oxido-4-quinolinyl)-2'-deoxyguanosine; 3-(dG-N2-yl)-4-AQO; 4-Aminoquinoline 1-oxide-deoxyguanosine adduct; dG-C8-4-AQO (common misnomer for N2 adduct); N2-(4-Aminoquinoline-1-oxide-3-yl)-2'-deoxyguanosine; DNA Adduct of 4-Nitroquinoline 1-Oxide Metabolite; 4-HAQO-dG Adduct
EINECS	Contact for details

Quality Control

Every batch of 3-(Deoxyguanosin-N2-Yl)-4-Aminoquinoline 1-Oxide is manufactured and analyzed under strict quality protocols to ensure identity, purity, and stability for research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results from multiple orthogonal analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to molecular ion pattern
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.