Description

3,3',5-Triiodothyroacetic Acid Sulfate is a chemically modified derivative of thyroid hormone, specifically designed for research and development applications. This compound is valued for its role as a key intermediate and reference standard in the synthesis and study of thyroid hormone analogs and their metabolic pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers focused on endocrinology, metabolic disease research, and novel therapeutic agent development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel thyroid hormone receptor agonists and antagonists for therapeutic development.
• Biochemical Research: Used as a reference standard and probe in studies investigating thyroid hormone metabolism, transport, and deiodination pathways.
• Endocrinology Studies: Employed in *in vitro* and *in vivo* research models to understand the structure-activity relationships of thyroid hormone derivatives.
• Analytical Standard: Serves as a high-purity calibrant for analytical methods such as HPLC and LC-MS in pharmaceutical quality control and bioanalytical labs.
• Metabolic Pathway Investigation: A tool for studying the sulfation pathway of thyroid hormones and its implications in hormone regulation and disposal.
• Fine Chemical Synthesis: A specialized starting material for the preparation of labeled compounds (e.g., radioiodinated tracers) for diagnostic and research purposes.

Basic Information

Product Name	3,3',5-Triiodothyroacetic Acid Sulfate
CAS No.	95786-11-1
Molecular Formula	C14H10I3NO7S
Molecular Weight	752.99 g/mol
Synonyms	Triiodothyroacetic Acid Sulfate; TRIAC Sulfate; 3,3',5-Triiodothyroacetate Sulfate; Tiratricol Sulfate; TA3 Sulfate; (4-(4-Hydroxy-3-iodophenoxy)-3,5-diiodophenyl)acetic acid sulfate; Sulfuric acid mono-[2-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]-acetate]
EINECS	Contact for details

Quality Control

Our 3,3',5-Triiodothyroacetic Acid Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets exacting standards for research and development use. Certificates of Analysis (COA) with detailed chromatographic data and batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.