Description

L-Thyronine is a synthetic thyroid hormone analog, also known as liothyronine or T3. This high-purity active pharmaceutical ingredient (API) is critical for formulating precise and effective hormone replacement therapies and diagnostic agents. It is primarily required by pharmaceutical manufacturers, research institutions, and diagnostic kit producers for applications in endocrinology and metabolic research.

Application

• Pharmaceutical Formulations: As the active ingredient in synthetic thyroid hormone medications (e.g., liothyronine sodium) for treating hypothyroidism and thyroid cancer.
• Clinical Research: Used in metabolic and endocrine studies to investigate thyroid hormone function, receptor activity, and signaling pathways.
• Diagnostic Reagents: A key component in the development of immunoassays and test kits for measuring thyroid-stimulating hormone (TSH) and related hormones.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method validation in pharmaceutical laboratories.
• Biochemical Research: Employed in cell culture and animal studies to model thyroid hormone effects on development, metabolism, and gene expression.
• Veterinary Medicine: Used in formulations for treating thyroid disorders in companion animals and livestock.

Basic Information

Item	Details
Product Name	L-Thyronine
CAS No.	1596-67-4
Molecular Formula	C15H12I3NO4
Molecular Weight	650.97 g/mol
Synonyms	Liothyronine; T3; 3,3',5-Triiodo-L-thyronine; Triiodothyronine; O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine; Thybon; Cytomel; Tertroxin; Triostat; L-3,3',5-Triiodothyronine
EINECS	216-458-8

Quality Control

Our L-Thyronine is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards suitable for pharmaceutical applications, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to handle under an inert atmosphere for long-term storage and to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.