Description

(2'S)-2'-Deoxy-2'-Fluoro-5-Ethynyluridine is a fluorinated nucleoside analog, a key building block in medicinal chemistry and oligonucleotide synthesis. Its modified sugar moiety, featuring a fluorine atom at the 2' position, and the reactive ethynyl group at the 5 position make it a versatile intermediate for creating novel therapeutics and research probes. This compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing antiviral agents, antisense oligonucleotides, and diagnostic tools.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Antisense Oligonucleotide (ASO) Synthesis: Used in the solid-phase synthesis of modified oligonucleotides for gene silencing and therapeutic applications.
• Probe Development: The ethynyl group enables click chemistry for labeling and conjugation in bioconjugation and diagnostic assay development.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies related to nucleotide metabolism and polymerase function.
• Precision Medicine Tools: Component in the development of targeted molecular probes for imaging and therapeutic delivery systems.

Basic Information

Product Name	(2'S)-2'-Deoxy-2'-Fluoro-5-Ethynyluridine
CAS No.	95740-26-4
Molecular Formula	C11H11FN2O5
Molecular Weight	270.21 g/mol
Synonyms	2'-Deoxy-2'-fluoro-5-ethynyluridine; 5-Ethynyl-2'-deoxy-2'-fluorouridine; 2'-F-5-Ethynyl-dU; 1-((2S,4R,5R)-4-Fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpyrimidine-2,4(1H,3H)-dione; 5-Ethynyl-1-(2-deoxy-2-fluoro-β-D-ribofuranosyl)uracil; FdU-Ethynyl; 2'-F-5-EUrd
EINECS	Contact for details

Quality Control

Our (2'S)-2'-Deoxy-2'-Fluoro-5-Ethynyluridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.