Description

3-Azidopyrimethamine is a specialized chemical building block featuring an azide functional group, derived from the antimalarial compound pyrimethamine. This compound is of significant value in pharmaceutical research and development, particularly in the synthesis of novel drug candidates and bioconjugates via click chemistry. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in medicinal chemistry, proteomics, and the development of targeted therapeutics.

Application

• Medicinal Chemistry Intermediate: A key precursor for the synthesis of novel antimalarial and antiparasitic drug candidates through structure-activity relationship (SAR) studies.
• Bioconjugation & Probe Development: Enables site-specific labeling of biomolecules (proteins, antibodies, nucleic acids) via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for diagnostic and imaging applications.
• Chemical Biology Research: Used as a chemical probe to study enzyme inhibition, particularly dihydrofolate reductase (DHFR), and to investigate cellular pathways.
• Pharmaceutical R&D: Serves as a versatile scaffold for creating libraries of compounds for high-throughput screening against various therapeutic targets.
• Academic Research: Employed in universities and research institutes for fundamental studies in organic synthesis, heterocyclic chemistry, and drug discovery methodologies.

Basic Information

Product Name	3-Azidopyrimethamine
CAS No.	95458-40-5
Molecular Formula	C₁₂H₁₁N₇
Molecular Weight	253.26 g/mol
Synonyms	3-Azido-5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine; 3-Azido-5-(p-chlorophenyl)-6-ethyl-2,4-pyrimidinediamine; Azidopyrimethamine; 3-Azido-pyrimethamine; 5-(4-Chlorophenyl)-3-azido-6-ethyl-2,4-pyrimidinediamine; NSC 339586
EINECS	Contact for details

Quality Control

Our 3-Azidopyrimethamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support research and development with material that meets exacting standards for traceability and reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its light-sensitive nature, the container should be opaque or stored in dark conditions. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.