Description

2-(tert-Butyldimethylsilyl)-1,3-Dithiane CAS NO 95452-06-5 is a specialized organosilicon-protected dithiane reagent, a key building block in advanced organic synthesis. Its primary value lies in its role as a robust, sterically hindered protecting group for carbonyl compounds, enabling complex multi-step reactions with high selectivity and yield. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require precise control over synthetic pathways.

Application

• Carbonyl Protection in Pharmaceutical Intermediates: Serves as a critical masked acyl anion equivalent for the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used in the construction of chiral centers for the production of enantiomerically pure compounds in medicinal chemistry.
• Natural Product Synthesis: Facilitates the multi-step total synthesis of complex natural products by protecting sensitive functional groups.
• Agrochemical Research: Employed in the development of novel pesticides and herbicides where specific molecular architecture is required.
• Material Science Precursor: Acts as a precursor for the development of novel organic materials and ligands for catalysis.
• Academic & Process R&D: A valuable tool in research laboratories for developing new synthetic methodologies and scalable processes.

Basic Information

Product Name	2-(tert-Butyldimethylsilyl)-1,3-Dithiane
CAS No.	95452-06-5
Molecular Formula	C10H22S2Si
Molecular Weight	234.50 g/mol
Synonyms	2-(tert-Butyldimethylsilyl)-1,3-dithiane; 2-(Tert-butyldimethylsilyl)-1,3-dithiane; 1,3-Dithiane, 2-[(1,1-dimethylethyl)dimethylsilyl]-; 2-(tert-Butyldimethylsilyl)dithiane; 2-TBDMS-1,3-dithiane; 2-(TBDMS)-1,3-dithiane; 2-(tert-Butyl-dimethyl-silyl)-[1,3]dithiane; TBDMS-Dithiane
EINECS	Contact for details

Quality Control

Our 2-(tert-Butyldimethylsilyl)-1,3-Dithiane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee consistency and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.