Description

N4-Benzoyl-7-Deaza-2'-Deoxyadenosine is a high-purity, protected nucleoside analog crucial for advanced oligonucleotide synthesis and medicinal chemistry research. This compound serves as a key building block for the development of modified DNA and RNA sequences, enabling the creation of stable, high-affinity probes and therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on antisense technology, diagnostic assay development, and novel therapeutic modalities.

Application

• Oligonucleotide Synthesis: A critical phosphoramidite precursor for the solid-phase synthesis of oligonucleotides containing 7-deaza-2'-deoxyadenosine modifications.
• Antisense & siRNA Research: Used in the development of antisense oligonucleotides and small interfering RNA (siRNA) with enhanced nuclease resistance and binding affinity.
• Diagnostic Probe Development: Employed in the manufacture of labeled probes and primers for PCR, sequencing, and hybridization assays requiring high specificity.
• Medicinal Chemistry & Drug Discovery: Serves as a scaffold for synthesizing nucleoside analog libraries and investigating novel antiviral or anticancer agents.
• Structural Biology Studies: Incorporated into DNA strands for X-ray crystallography and NMR studies to understand nucleic acid structure and protein interactions.
• Bioconjugation & Labeling: The benzoyl protecting group provides a handle for further chemical modifications and attachment of reporter molecules like fluorophores.

Basic Information

Product Name	N4-Benzoyl-7-Deaza-2'-Deoxyadenosine
CAS No.	95261-09-9
Molecular Formula	C₁₇H₁₇N₅O₄
Molecular Weight	355.35 g/mol
Synonyms	7-Deaza-2'-deoxyadenosine, N4-benzoyl-; 4-Benzamido-7-(2-deoxy-β-D-erythro-pentofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine; N4-Benzoyl-7-deaza-2'-deoxyadenosine; 7-Deaza-dA(Bz); Bz-7-deaza-dA; N4-Bz-7-deaza-2'-deoxyadenosine; Protected 7-Deaza-2'-deoxyadenosine; 4-(Benzoylamino)-7-(2-deoxy-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Every batch of N4-Benzoyl-7-Deaza-2'-Deoxyadenosine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the stringent requirements of research and pre-clinical development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as assay (HPLC), purity profile, and confirmation of structure.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0% (Total area)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.