Description

1-(3-Bromopropyl)-2,2,5,5-Tetramethyl-1-Aza-2,5-Disilacyclopentane is a specialized organosilicon reagent featuring a protected amine (aza) group and a reactive bromopropyl handle. This compound is valued for its role as a key synthetic intermediate in advanced organic and medicinal chemistry, enabling the controlled introduction of functionalized amine moieties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing linker arms or side chains in drug candidates.
• Peptide Mimetics & PROTACs: Serves as a building block for creating peptide-like structures and proteolysis-targeting chimeras (PROTACs) due to its protected amine functionality.
• Ligand & Catalyst Synthesis: Employed in the preparation of novel ligands for catalysis or as a precursor for functionalized silane-based catalysts.
• Surface Modification Agent: Can be used to functionalize silica or other surfaces with amine groups after deprotection and immobilization.
• Polymer & Dendrimer Chemistry: Acts as a monomer or branching unit in the synthesis of specialty polymers and dendrimers with tailored properties.
• Cross-coupling Reactions: The bromopropyl group participates in various cross-coupling reactions (e.g., Suzuki, Heck) for carbon-carbon bond formation.

Basic Information

Product Name	1-(3-Bromopropyl)-2,2,5,5-Tetramethyl-1-Aza-2,5-Disilacyclopentane
CAS No.	95091-93-3
Molecular Formula	C10H24BrNSi2
Molecular Weight	298.38 g/mol
Synonyms	3-Bromopropyl-1,1,3,3-tetramethyl-1,3-diaza-2-silacyclopentane; 1-Aza-2,5-disilacyclopentane, 1-(3-bromopropyl)-2,2,5,5-tetramethyl-; (3-Bromopropyl)(tetramethyl-1,3-diaza-2-silacyclopent-1-yl)silane; Bromopropyl TMDAS; N-(3-Bromopropyl)-1,1,3,3-tetramethyldisilazacyclopentane; Protected 3-bromopropylamine silane reagent
EINECS	Contact for details

Quality Control

Our 1-(3-Bromopropyl)-2,2,5,5-Tetramethyl-1-Aza-2,5-Disilacyclopentane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, GC, and HPLC, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Purity (HPLC)	≥ 94.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.