Description

2'-Deoxy-2',2'-Difluoro Thymidine is a fluorinated nucleoside analog, a critical building block in the synthesis of advanced pharmaceutical compounds. Its primary value lies in its role as a key intermediate for the production of potent antiviral and anticancer agents, most notably the active metabolite of the chemotherapeutic drug Gemcitabine. This high-purity intermediate is essential for pharmaceutical R&D laboratories and manufacturers engaged in the synthesis of nucleoside-based therapeutics. Ensuring a reliable supply of this material with stringent quality control is paramount for downstream drug development and production.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor for the manufacture of Gemcitabine (Gemzar®), a widely used chemotherapy medication.
• Antiviral Drug Synthesis: Serves as a building block in the research and development of novel nucleoside analog antiviral agents.
• Oncology Research: Utilized in biochemical and pharmacological studies to investigate mechanisms of action for anticancer nucleosides.
• Process Chemistry & Scale-Up: Employed in optimizing and scaling synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Biochemical Tool: Applied in enzymatic studies and as a substrate analog to study DNA polymerase inhibition.

Basic Information

Product Name	2'-Deoxy-2',2'-Difluoro Thymidine
CAS No.	95058-80-3
Molecular Formula	C10H12F2N2O5
Molecular Weight	278.21 g/mol
Synonyms	2',2'-Difluorodeoxythymidine; 2'-Deoxy-2',2'-difluorothymidine; dFdT; 1-(2-Deoxy-2,2-difluoro-β-D-erythro-pentofuranosyl)thymine; 2'-Deoxy-2',2'-difluoro-5-methyluridine; Gemcitabine Intermediate; DFDT
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2',2'-Difluoro Thymidine is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical intermediate applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support compliance with GMP, ICH Q7, and other relevant regulatory guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.