Description

5-o-(Dimethoxytrityl)-1,2-Dideoxy-D-Ribose is a key protected nucleoside intermediate essential for the synthesis of oligonucleotides and modified nucleic acids. Its primary value lies in providing a reactive site for controlled phosphoramidite coupling while protecting the 5'-hydroxyl group with the acid-labile dimethoxytrityl (DMT) moiety. This compound is critically needed by manufacturers and research institutions in the pharmaceutical, biotechnology, and diagnostic sectors for producing antisense oligonucleotides, primers, probes, and other therapeutic nucleic acid constructs.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): As a crucial building block in automated phosphoramidite chemistry for constructing DNA/RNA sequences.
• Antisense Oligonucleotide (ASO) Production: For the manufacturing of therapeutic oligonucleotides targeting genetic diseases.
• siRNA and miRNA Synthesis: Enables the production of short interfering RNA and microRNA for gene silencing research and therapeutics.
• Diagnostic Probe Development: Used in creating labeled probes for PCR, FISH, and microarray technologies.
• Research & Development: Serves as a starting material in academic and industrial labs for novel nucleoside analog development.
• Pharmaceutical Intermediates: A key precursor in the synthesis of nucleoside-based antiviral and anticancer drug candidates.

Basic Information

Product Name	5-o-(Dimethoxytrityl)-1,2-Dideoxy-D-Ribose
CAS No.	95049-01-7
Molecular Formula	C26H28O5
Molecular Weight	420.50 g/mol
Synonyms	1,2-Dideoxy-5-O-(4,4'-dimethoxytrityl)-D-ribofuranose; 5'-O-DMT-1,2-dideoxyribose; 5-O-(4,4'-Dimethoxytrityl)-1,2-dideoxy-D-ribofuranose; DMT-1,2-dideoxyribose; 1,2-Dideoxy-5-O-DMT-ribose; 5-O-Dimethoxytrityl-1,2-dideoxy-D-ribofuranose
EINECS	Contact for details

Quality Control

Our 5-o-(Dimethoxytrityl)-1,2-Dideoxy-D-Ribose is manufactured under strict quality systems suitable for pharmaceutical intermediate applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting standards for oligonucleotide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.