Description

1-Acetylisonipecotoyl Chloride is a high-purity, reactive chemical intermediate belonging to the class of acid chlorides derived from isonipecotic acid. This compound is critical for introducing the 1-acetylpiperidine-4-carbonyl moiety into target molecules, enabling the synthesis of complex pharmacologically active structures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where its structural motif can contribute to biological activity.
• Peptide Mimetics & PROTACs: Serves as a versatile linker or coupling agent in the development of peptide analogs and Proteolysis Targeting Chimeras (PROTACs).
• Chemical Research: Employed in academic and industrial R&D labs for method development and exploring new chemical entities.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.

Basic Information

Product Name	1-Acetylisonipecotoyl Chloride
CAS No.	95037-48-2
Molecular Formula	C8H12ClNO2
Molecular Weight	189.64 g/mol
Synonyms	1-Acetyl-4-piperidinecarbonyl chloride; 1-Acetylpiperidine-4-carbonyl chloride; 4-(Chlorocarbonyl)-1-acetylpiperidine; Isonipecotoyl chloride, 1-acetyl-; N-Acetyl-4-piperidinecarbonyl chloride
EINECS	Contact for details

Quality Control

Our 1-Acetylisonipecotoyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.