Description

Cytidine-5'-o-Dimethylphosphate CAS NO 94369-26-3 is a chemically modified nucleoside derivative where the 5'-hydroxyl group of cytidine is phosphorylated with two methyl groups. This modification is crucial for its role as a key synthetic intermediate and building block in the production of more complex nucleotide analogs and prodrugs. It is primarily required by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer therapeutics, and novel oligonucleotide-based technologies.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Oligonucleotide Synthesis: Used as a modified phosphoramidite or monomer in the solid-phase synthesis of custom DNA/RNA sequences for research and diagnostics.
• Prodrug Development: Acts as a building block for creating membrane-permeable prodrugs of bioactive nucleoside monophosphates.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide metabolism and related pathways.
• Labeled Compound Synthesis: A starting material for the preparation of isotopically labeled (e.g., 13C, 15N) nucleotides for metabolic tracing and NMR studies.

Basic Information

Product Name	Cytidine-5'-o-Dimethylphosphate
CAS No.	94369-26-3
Molecular Formula	C11H18N3O7P
Molecular Weight	335.25 g/mol
Synonyms	5'-O-Dimethylphosphorylcytidine; Cytidine 5'-(dimethyl phosphate); Cytidine 5'-monophosphate dimethyl ester; 5'-Dimethyl phosphate cytidine; 1-[(2R,3S,4R,5R)-5-[(Dimethoxyphosphoryl)oxy]-3,4-dihydroxyoxolan-2-yl]-4-aminopyrimidin-2-one
EINECS	Contact for details

Quality Control

Our Cytidine-5'-o-Dimethylphosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.