Description

O(6)-Ethylthioethyldeoxyguanosine is a chemically modified nucleoside derivative, specifically an alkylated guanine analog, designed for advanced biochemical and pharmaceutical research. This compound is of significant value for its role in studying DNA alkylation damage, repair mechanisms, and as a critical building block in the development of oligonucleotide-based therapeutics. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in oncology research, molecular biology, and the synthesis of novel nucleic acid analogs.

Application

• Biochemical Research: A key reagent for investigating the mechanisms and consequences of O6-alkylguanine DNA adduct formation and repair.
• Pharmaceutical Development: Serves as a sophisticated intermediate in the synthesis of modified antisense oligonucleotides, siRNA, or aptamers for therapeutic applications.
• Oncology Studies: Used in research focused on DNA damage response pathways and the development of strategies to overcome chemoresistance, particularly to alkylating agents.
• Enzyme Substrate Studies: Acts as a specific substrate for studying the activity of DNA repair enzymes such as O6-alkylguanine-DNA alkyltransferase (AGT).
• Probe Synthesis: Utilized in the creation of labeled or tagged nucleotide probes for diagnostic assays and genomic research.
• Standards and References: Provides a high-purity analytical standard for the quantification and identification of specific DNA lesions in complex biological samples.

Basic Information

Product Name	O(6)-Ethylthioethyldeoxyguanosine
CAS No.	94344-92-0
Molecular Formula	C14H21N5O4S
Molecular Weight	355.41 g/mol
Synonyms	O6-(2-Ethylthioethyl)-2'-deoxyguanosine; 2'-Deoxy-O6-(2-ethylthioethyl)guanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(2-ethylsulfanylethoxy)-1H-purin-2-one; O6-Ethylthioethyl-dG; ETEdG; Alkylated Deoxyguanosine Derivative
EINECS	Contact for details

Quality Control

Every batch of O(6)-Ethylthioethyldeoxyguanosine is subjected to rigorous analytical testing to ensure identity, purity, and consistency suitable for sensitive research applications. Our quality protocols include comprehensive characterization by HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with the agreed specifications for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere or with desiccant to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.