Description

Benzyl Chloroformate is a versatile and highly reactive benzyloxycarbonyl (Cbz) protecting agent widely used in organic synthesis. Its primary value lies in its ability to selectively protect amine groups, a critical step in the multi-step synthesis of complex molecules like peptides and pharmaceuticals. This compound is essential for research laboratories and production facilities in the pharmaceutical, agrochemical, and fine chemical industries that require high-purity intermediates for advanced synthesis.

Application

• Peptide Synthesis: As a key reagent for introducing the Cbz (carbobenzyloxy) protecting group onto amino acids, facilitating controlled chain elongation.
• Pharmaceutical Intermediates: Used in the synthesis of active pharmaceutical ingredients (APIs) and other complex drug candidates requiring amine protection.
• Agrochemical Manufacturing: Serves as a building block in the production of certain herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, dyes, and catalysts where selective functionalization is needed.
• Academic & Industrial Research: A fundamental tool in medicinal chemistry and process development for exploring new synthetic pathways.
• Polymer Chemistry: Can be utilized in the synthesis of specialized polymers and functional materials.

Basic Information

Product Name	Benzyl Chloroformate
CAS No.	94274-21-2
Molecular Formula	C8H7ClO2
Molecular Weight	170.59 g/mol
Synonyms	Benzyloxycarbonyl chloride; Cbz-Cl; Carbobenzyloxy chloride; Chloroformic acid benzyl ester; Benzyl chlorocarbonate; Benzyloxycarbonylchloride; NSC 8424; Z-Cl
EINECS	Contact for details

Quality Control

Our Benzyl Chloroformate is produced under stringent quality management systems. Every batch undergoes rigorous analytical testing, including assay and impurity profile analysis by techniques such as GC and HPLC, to ensure it meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing specific results is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated). Due to its hygroscopic and reactive nature, it should be kept under an inert atmosphere (e.g., nitrogen or argon) and separated from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.195 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.