Description

22-Thiacholesterol is a sulfur-containing steroidal compound, specifically a thio-analog of cholesterol, with the CAS number 94156-75-9. This modified sterol is of significant interest in advanced research and development, particularly for studying membrane biophysics, lipid-protein interactions, and as a potential synthetic intermediate for novel bioactive molecules. It is primarily utilized by research institutions, pharmaceutical R&D departments, and specialty chemical manufacturers engaged in steroid chemistry and material science.

Application

• Biochemical Research: Used as a probe or model compound in studies of lipid bilayer structure, membrane fluidity, and cholesterol trafficking mechanisms.
• Pharmaceutical Intermediates: Serves as a key synthetic building block for the development of novel therapeutic agents targeting lipid metabolism or sterol-related pathways.
• Material Science: Investigated for the development of advanced liquid crystals, sensors, or functional materials due to its modified sterol framework.
• Analytical Standards: Employed as a reference standard in chromatographic analysis (HPLC, GC) for the identification and quantification of sterol derivatives.
• Enzyme Studies: Acts as a substrate analog in enzymatic assays to study the activity and inhibition of enzymes involved in sterol biosynthesis or modification.

Basic Information

Product Name	22-Thiacholesterol
CAS No.	94156-75-9
Molecular Formula	C27H46OS
Molecular Weight	418.73 g/mol
Synonyms	22-Thia-5-cholesten-3β-ol; (3β)-22-Thia-5-cholesten-3-ol; 22-Thiacholest-5-en-3β-ol; Thiocholesterol derivative; Sulfur-substituted cholesterol; 22-Thiadesmosterol analog; Sterol thioether
EINECS	Contact for details

Quality Control

Our 22-Thiacholesterol is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods (NMR, IR, MS) for structural confirmation, to ensure identity, strength, and composition. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.