Description

Digitoxigenin is a key cardenolide aglycone, serving as the pharmacologically active core structure of the cardiac glycoside digitoxin. This high-purity reference standard is essential for research, development, and quality control in the pharmaceutical and life sciences sectors. It is primarily utilized by researchers and manufacturers in the pharmaceutical industry for analytical method development, biochemical studies, and as a critical starting material or intermediate in synthetic chemistry.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and impurity profiling of digitoxin and related cardiac glycosides in pharmaceutical products.
• Biochemical Research: Employed in studies investigating the mechanism of action of cardiac glycosides on the Na+/K+-ATPase pump and their effects on myocardial contractility.
• Organic Synthesis Intermediate: Serves as a crucial building block for the semi-synthesis of novel cardenolide derivatives with potential therapeutic applications.
• Analytical Chemistry: Acts as a calibration standard in chromatographic methods (HPLC, LC-MS) and spectroscopic analysis for quality control in drug manufacturing.
• Academic & Contract Research: Utilized in universities and CROs for pharmacological and toxicological research projects.

Basic Information

Product Name	Digitoxigenin
CAS No.	143-62-4
Molecular Formula	C23H34O4
Molecular Weight	374.51 g/mol
Synonyms	3β,14-Dihydroxy-5β-card-20(22)-enolide; (3β,5β)-3,14-Dihydroxycard-20(22)-enolide; Digitoxigenine; Gitoxigenin Impurity A; NSC 7526; Card-20(22)-enolide, 3,14-dihydroxy-, (3β,5β)-; 3β,14β-Dihydroxy-5β-card-20(22)-enolide
EINECS	205-617-4

Quality Control

Our Digitoxigenin is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production requirements. Specifications can be aligned with pharmacopeial standards (e.g., USP, EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	245 - 250 °C
Specific Rotation	+17° to +21° (c=1 in Dioxane)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.