Description

Cortexolone CAS NO 152-58-9 is a key steroid intermediate, specifically the 11-deoxy derivative of cortisol (hydrocortisone). This compound matters as a crucial building block in the synthesis of various glucocorticoids and other pharmacologically active steroids. It is primarily needed by pharmaceutical R&D and manufacturing sectors for the production of anti-inflammatory and corticosteroid APIs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of cortisol (hydrocortisone) and its synthetic analogs.
• Steroid Hormone Research: Used in biochemical and pharmacological studies to investigate glucocorticoid receptor activity and steroidogenesis pathways.
• API Manufacturing: Serves as a starting material or intermediate in the commercial production of various corticosteroid active pharmaceutical ingredients (APIs).
• Reference Standard: Employed as an analytical standard in quality control laboratories for HPLC or GC method development and validation.
• Biochemical Tool Compound: Utilized in vitro to study the effects of 11-deoxycortisol on specific enzymes like 11β-hydroxylase.

Basic Information

Product Name	Cortexolone
CAS No.	152-58-9
Molecular Formula	C21H30O4
Molecular Weight	346.46 g/mol
Synonyms	11-Deoxycortisol; 17α,21-Dihydroxypregn-4-ene-3,20-dione; Reichstein's Substance S; 11-Deoxy-17-hydroxycorticosterone; 17-Hydroxy-11-deoxycorticosterone; 21-Hydroxypregn-4-ene-3,20-dione
EINECS	205-803-6

Quality Control

Our Cortexolone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets exacting standards for pharmaceutical intermediate use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.