Description

Withaferin A is a bioactive steroidal lactone, a key withanolide compound derived from the medicinal plant Withania somnifera (Ashwagandha). It is highly valued for its potent and selective biological activity, making it a critical reference standard and research compound in modern life sciences. This product is essential for researchers and developers in the pharmaceutical, nutraceutical, and biotechnology sectors. Our supply ensures high purity and batch-to-batch consistency for reliable experimental and developmental outcomes.

Application

• Pharmaceutical Research & Development: Serves as a primary reference standard and active investigational compound for studying anti-cancer, anti-inflammatory, and neuroprotective mechanisms.
• Preclinical Studies: Used in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and toxicity profiles for potential drug candidates.
• Natural Product Standardization: Acts as a key marker compound for the quality control and standardization of Ashwagandha extracts and related herbal formulations.
• Biochemical Research: A vital tool for exploring cellular signaling pathways, apoptosis induction, and angiogenesis inhibition.
• Cosmeceutical Applications: Investigated for potential use in topical formulations targeting skin inflammation and oxidative stress.
• Academic Research: Supplied to universities and research institutes for fundamental studies in chemistry, biology, and pharmacology.

Basic Information

Product Name	Withaferin A
CAS No.	5119-48-2
Molecular Formula	C28H38O6
Molecular Weight	470.60 g/mol
Synonyms	Withaferine A; (22R)-5,6:22,26-Diepoxy-4β,27-dihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone; Withanolid A; NSC-101088
EINECS	Contact for details

Quality Control

Every batch of our Withaferin A is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical documentation to support your research and regulatory needs. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.