Description

Gitoxigenin 3-Acetate is a high-purity, semi-synthetic cardiac glycoside derivative, specifically an acetylated form of gitoxigenin. This compound is a critical reference standard and key intermediate in pharmaceutical research and development, particularly for the study of cardiotonic agents and their structure-activity relationships. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on cardiovascular drug discovery and analytical method development.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (e.g., HPLC, LC-MS) of cardiac glycosides in drug substances and finished products.
• Biochemical Research: Serves as a precise tool for studying the mechanism of action of Na+/K+-ATPase inhibition and related cardiac effects.
• Organic Synthesis Intermediate: Acts as a key building block for the semi-synthesis of novel cardiac glycoside derivatives and prodrugs.
• Academic Research: Employed in university and institutional labs for pharmacological studies and teaching purposes related to steroid and glycoside chemistry.
• Quality Control: Essential for in-house method validation and ensuring the purity and identity of related compounds in manufacturing environments.

Basic Information

Product Name	Gitoxigenin 3-Acetate
CAS No.	1059-21-8
Molecular Formula	C26H36O7
Molecular Weight	460.56 g/mol
Synonyms	Gitoxigenin 3-Monoacetate; 3β-Acetoxy-14,16β-dihydroxy-5β-card-20(22)-enolide; 16β-Hydroxydigitoxigenin 3-acetate; (3β,5β,16β)-3-(Acetyloxy)-14,16-dihydroxycard-20(22)-enolide; Gitoxigenin acetate; 16β-Hydroxy-3β-acetoxy-5β,14β-card-20(22)-enolide; 3-Acetyl gitoxigenin
EINECS	Contact for details

Quality Control

Our Gitoxigenin 3-Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and specific tests for related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.