Description

P1,P5-Di(Adenosine-5'-)Pentaphosphate, Trilithium Salt is a high-purity, chemically defined dinucleotide analog of significant biochemical interest. This compound serves as a potent and specific inhibitor of adenylate kinase, making it a critical tool for researchers studying nucleotide metabolism, energy transfer, and signal transduction pathways. It is essential for pharmaceutical R&D, academic biochemistry, and diagnostic assay development where precise enzymatic control is required.

Application

• Biochemical Research: As a specific inhibitor of adenylate kinase (AK) isoforms (AK1, AK2, AK5) to study cellular energy homeostasis and nucleotide metabolism.
• Pharmaceutical Development: Used in target validation and screening assays for drug discovery programs focused on metabolic disorders, cardiovascular diseases, and cancer.
• Diagnostic Reagents: A key component in enzymatic assay kits for the determination of ATP, ADP, and AMP levels in clinical and research samples.
• Enzymology Studies: Employed to investigate the kinetics and mechanism of adenylate kinase and related phosphotransferase enzymes.
• Cell Signaling Research: Useful for probing the role of adenylate kinase in intracellular compartmentalized phosphotransfer networks and signal amplification.
• Reference Standard: Serves as a certified reference material (CRM) for quality control in the production of diagnostic and research reagents.

Basic Information

Product Name	P1,P5-Di(Adenosine-5'-)Pentaphosphate, Trilithium Salt
CAS No.	94108-02-8
Molecular Formula	C20H21Li3N10O22P5
Molecular Weight	915.13 g/mol
Synonyms	Ap5A, Lithium Salt; Diadenosine pentaphosphate, Trilithium salt; P1,P5-Di(adenosine-5')pentaphosphate; Adenosine pentaphosphate derivative; Adenylate kinase inhibitor; APPPPA; 5'-Adenylyl (P1→P5)-pentaphospho-(P5→1)-5'-adenosine, Trilithium salt
EINECS	Contact for details

Quality Control

Our P1,P5-Di(Adenosine-5'-)Pentaphosphate, Trilithium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep frozen. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Heavy Metals	≤ 20 ppm
Biological Activity (AK Inhibition)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.