Description

n-Benzoyl-5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-Deoxyadenosine 3'-Benzoate is a key, high-purity protected nucleoside derivative used as a critical building block in oligonucleotide synthesis. This compound is essential for researchers and manufacturers requiring precise control over nucleic acid sequences, enabling the development of advanced therapeutics and diagnostic tools. It is primarily utilized in the pharmaceutical and biotechnology sectors for the production of antisense oligonucleotides, siRNA, and other novel genetic medicines.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a protected 2'-deoxyadenosine phosphoramidite precursor for automated DNA synthesis.
• Antisense Oligonucleotide (ASO) Manufacturing: A critical raw material in the production of therapeutic ASOs targeting genetic diseases.
• siRNA and miRNA Synthesis: Used in the construction of short interfering RNA (siRNA) and microRNA (miRNA) strands for gene silencing applications.
• Diagnostic Probe Development: Employed in the synthesis of labeled DNA probes for molecular diagnostics and hybridization assays.
• Research & Development: A vital reagent for academic and industrial R&D in molecular biology, genetics, and medicinal chemistry.
• Pharmaceutical Intermediates: Acts as a sophisticated intermediate in the multi-step synthesis of nucleotide-based active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	n-Benzoyl-5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-Deoxyadenosine 3'-Benzoate
CAS No.	93966-66-6
Molecular Formula	C51H43N5O8
Molecular Weight	854.93 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N-benzoyl-2'-deoxyadenosine 3'-O-benzoate; DMTr-dABz(bz); N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine 3'-O-benzoate; 2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)-N-benzoyladenosine 3'-(benzoate); Protected 2'-Deoxyadenosine Derivative; dA(Bz) DMTr Benzoate
EINECS	Contact for details

Quality Control

Every batch of n-Benzoyl-5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-Deoxyadenosine 3'-Benzoate is manufactured and tested under strict quality management systems to ensure it meets the high-purity standards required for sensitive synthetic applications. Our rigorous quality testing includes HPLC for purity, NMR for structural confirmation, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.