Description

Benzyl Fluoroformate is a specialized fluorinated reagent used as a key building block in organic synthesis. This compound is valued for its role in introducing protective groups and facilitating the synthesis of complex molecules, particularly in pharmaceutical research and development. It serves as a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors seeking to develop novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for introducing benzyloxycarbonyl (Cbz) protecting groups in peptide and nucleotide chemistry.
• Agrochemical Synthesis: Used in the research and production of fluorinated pesticides and herbicides, where the fluorine atom can enhance biological activity and stability.
• Peptide Chemistry: Functions as a fluoroformylating agent for the temporary protection of amine groups during solid-phase and solution-phase peptide synthesis.
• Material Science Research: Employed in the development of specialty polymers and advanced organic materials that incorporate fluorine for specific thermal or chemical resistance properties.
• Chemical Biology Probes: Utilized in the creation of fluorinated probes and tags for studying biological processes and enzyme mechanisms.
• Cross-Coupling Reactions: Acts as a reagent in palladium-catalyzed cross-coupling reactions to construct complex organic frameworks.

Basic Information

Item	Detail
Product Name	Benzyl Fluoroformate
CAS No.	93942-41-7
Molecular Formula	C8H7FO2
Molecular Weight	154.14 g/mol
Synonyms	Benzyl Fluoroformate; Benzyl Carbonochloridate; Benzyl Chloroformate; Benzyloxycarbonyl Fluoride; Cbz-F; Fluoroformic Acid Benzyl Ester; Benzyl Fluoroformate Reagent; (Benzyloxy)carbonyl Fluoride
EINECS	Contact for details

Quality Control

Our Benzyl Fluoroformate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its moisture-sensitive (hygroscopic) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.