Description

4-Thiothymidine 3',5'-Dibenzoate is a chemically modified nucleoside derivative, specifically a thymidine analog where the oxygen at the 4-position of the pyrimidine ring is replaced by sulfur and the 3' and 5' hydroxyl groups are protected as benzoate esters. This compound is a crucial synthetic intermediate and building block in advanced organic and medicinal chemistry research. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the development of novel therapeutic agents, particularly in the areas of antiviral and anticancer drug discovery.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of modified oligonucleotides and nucleoside analogs with potential antiviral or anticancer activity.
• Antisense Oligonucleotide Research: Used in the development of antisense and siRNA therapeutics, where modified nucleosides enhance stability and binding affinity.
• Proteomics & Diagnostics: Can serve as a component in the synthesis of probes and markers for biochemical assays and diagnostic tools.
• Chemical Biology Studies: Employed to study enzyme mechanisms, particularly those of nucleoside-processing enzymes like kinases and polymerases.
• Academic & Industrial R&D: A valuable reagent for universities and contract research organizations (CROs) exploring novel nucleic acid chemistry and drug discovery pathways.

Basic Information

Product Name	4-Thiothymidine 3',5'-Dibenzoate
CAS No.	93841-35-1
Molecular Formula	C24H22N2O6S
Molecular Weight	466.51 g/mol
Synonyms	1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-2-sulfanylidene-pyrimidin-4-one 3',5'-Dibenzoate; 4-Thio-2'-deoxythymidine 3',5'-Dibenzoate; 4-Thio-dT 3',5'-Dibenzoate; 2'-Deoxy-4-thiothymidine 3',5'-Dibenzoate; 4-Thiothymidine dibenzoate; 4-S-dThd(Bz)2
EINECS	Contact for details

Quality Control

Our 4-Thiothymidine 3',5'-Dibenzoate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or manufacturing protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.