Description

5-Azidonaphthoic Acid is a specialized aromatic azido-carboxylic acid derivative, serving as a versatile photoaffinity labeling reagent and click chemistry precursor. Its value lies in its ability to form covalent bonds upon UV irradiation or participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, enabling precise biomolecular tagging and probe synthesis. This compound is essential for researchers and manufacturers in pharmaceutical development, chemical biology, and materials science, where it is used to create targeted probes, study protein-ligand interactions, and functionalize polymers.

Application

• Photoaffinity Labeling (PAL): A critical reagent for mapping biological interaction sites by forming irreversible crosslinks with target proteins upon UV light activation.
• Click Chemistry Synthesis: Serves as a key azide component in CuAAC reactions for the modular construction of complex molecules, bioconjugates, and chemical libraries.
• Proteomics & Chemical Biology: Used to develop activity-based probes (ABPs) for profiling enzyme activity and studying metabolic pathways in living systems.
• Polymer & Materials Functionalization: Enables the introduction of reactive azide groups onto polymer backbones or material surfaces for subsequent modification.
• Pharmaceutical Intermediate: Acts as a building block in the synthesis of novel drug candidates, particularly those incorporating triazole linkages.
• Diagnostic Reagent Development: Utilized in the creation of labeled antibodies, antigens, or other detection molecules for diagnostic assays.

Basic Information

Product Name	5-Azidonaphthoic Acid
CAS No.	93835-65-5
Molecular Formula	C11H7N3O2
Molecular Weight	213.19 g/mol
Synonyms	5-Azido-1-naphthoic Acid; 5-Azido-1-naphthalenecarboxylic Acid; 1-Naphthoic Acid, 5-azido-; 5-Azidonaphthalene-1-carboxylic Acid; Azidonaphthoic Acid; PAL Reagent; Click Chemistry Azide; Naphthalene Azido Acid
EINECS	Contact for details

Quality Control

Our 5-Azidonaphthoic Acid is produced and tested under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemicals, and custom synthesis and purification to meet specific project requirements are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the product label/COA. For long-term storage under inert atmosphere, consult the technical data sheet. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.