Description

3'-Acetyl-3,5-Diiodothyronine is a chemically modified derivative of the thyroid hormone thyronine, characterized by the acetylation of the 3' phenolic hydroxyl group and iodination at the 3 and 5 positions. This compound serves as a critical intermediate and reference standard in pharmaceutical research and development, particularly for studying thyroid hormone metabolism, receptor binding, and the synthesis of novel analogs. It is primarily utilized by research institutions, pharmaceutical companies, and fine chemical manufacturers engaged in endocrinology, drug discovery, and the production of high-purity biochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthetic pathway for novel thyroid hormone analogs and potential therapeutic agents.
• Biochemical Research: Used as a reference standard and reagent in studies investigating thyroid hormone action, metabolism, and structure-activity relationships (SAR).
• Metabolite Standard: Essential for the analytical quantification of thyroid hormone metabolites in biological samples via HPLC or LC-MS methods.
• Endocrinology Studies: Applied in in vitro and in vivo research to understand the effects of hormone modification on biological activity.
• Fine Chemical Synthesis: Serves as a specialized starting material for the custom synthesis of labeled compounds (e.g., deuterated or radioiodinated versions) for tracer studies.
• Quality Control: Employed as an impurity marker or system suitability standard in the quality assurance of thyroid hormone APIs (Active Pharmaceutical Ingredients).

Basic Information

Product Name	3'-Acetyl-3,5-Diiodothyronine
CAS No.	93800-43-2
Molecular Formula	C15H11I2NO4
Molecular Weight	538.06 g/mol
Synonyms	O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine 3'-Acetate; 3'-Acetyl-3,5-diiodo-L-thyronine; 3,5-Diiodo-O-(4-hydroxy-3,5-diiodophenyl)-L-tyrosine Acetate (ester); 3,5-Diiodothyronine 3'-Acetate; N-Acetyl-3,5-diiodothyronine; 3'-Acetyl-T2; Acetyl Diiodothyronine
EINECS	Contact for details

Quality Control

Our 3'-Acetyl-3,5-Diiodothyronine is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay, related substances, and residual solvents. Our quality commitment aligns with the standards expected for pharmaceutical intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.