Description

Teicoplanin A3-1 is a principal component of the teicoplanin complex, a clinically significant glycopeptide antibiotic. This high-purity reference standard is critical for analytical research, quality control, and the development of novel antibacterial agents. It is essential for pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of antibiotic products requiring precise quantification and characterization.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and impurity profiling of teicoplanin in drug substances and finished products via HPLC, LC-MS, and other analytical methods.
• Antibacterial Research: Serves as a key compound in microbiological studies to investigate mechanisms of action, resistance patterns, and structure-activity relationships (SAR) of glycopeptide antibiotics.
• Quality Control & Assurance: Employed in the in-house testing and validation of teicoplanin-based pharmaceuticals to ensure batch-to-batch consistency, potency, and compliance with pharmacopeial standards (USP, EP).
• Method Development & Validation: Critical for developing, optimizing, and validating new analytical methods for the detection and quantification of teicoplanin components in complex matrices.
• Impurity Characterization: Used to identify and quantify related substances and degradation products during the stability testing and shelf-life determination of teicoplanin formulations.

Basic Information

Product Name	Teicoplanin A3-1
CAS No.	93616-27-4
Molecular Formula	C₈₈H₉₅Cl₂N₉O₃₃
Molecular Weight	1877.6 g/mol
Synonyms	Teicoplanin A3-1; Antibiotic MDL 621; Teichomycin A3-1; T-A3-1; (3S,6R,9R,12S,15R,18S,21S,24S,30S,33S)-30-[[2-[(Aminoacetyl)amino]acetyl]amino]-3-[(2-amino-2-oxoethyl)amino]-15-[[2-(aminomethyl)phenyl]methyl]-12-benzyl-6-[(1R)-1-hydroxyethyl]-21-(4-hydroxyphenyl)methyl]-18-[(1R)-1-methoxyethyl]-9,24-dimethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-33-[[2-oxo-2-[(10,11,12,13-tetrahydro-6,9,13-trihydroxy-8-methoxy-4-methyl-5-oxo-5H-tetracen-2-yl)oxy]ethyl]amino]-1H,4H,7H,10H,13H,16H,19H,22H,25H,28H,31H-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontin-33-yl 2-(acetylamino)-2-deoxy-β-D-glucopyranoside
EINECS	Contact for details

Quality Control

Our Teicoplanin A3-1 is manufactured and tested under strict quality management systems. Each batch undergoes comprehensive analysis to ensure identity, purity, and potency, aligning with the requirements for a high-grade reference material. A detailed Certificate of Analysis (COA) is provided, documenting results for assay, related substances, residual solvents, and other critical parameters. We support compliance with major pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥95.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤5.0% Any single impurity ≤2.0%
Water Content (KF)	≤8.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.