Description

Sp-Adenosine 3',5'-Cyclic Monophosphothioate Triethylamine is a chemically modified, non-hydrolyzable analog of cyclic adenosine monophosphate (cAMP). This compound is a critical research tool in molecular biology and pharmacology, valued for its ability to selectively activate protein kinase A (PKA) and study cAMP-mediated signaling pathways. It is essential for scientists and manufacturers in pharmaceutical R&D, biochemical research, and diagnostic assay development.

Application

• Biochemical Research: As a potent and specific activator of protein kinase A (PKA) for studying intracellular signal transduction.
• Pharmaceutical Development: Used in high-throughput screening (HTS) assays to identify and characterize novel drug candidates targeting the cAMP-PKA pathway.
• Cell Biology Studies: Investigating the role of cAMP in cellular processes such as metabolism, gene expression, and ion channel regulation.
• Diagnostic Reagents: A key component in ELISA and other immunoassays for the detection and quantification of cAMP-related biological activity.
• Enzymology: Serves as a substrate analog in enzymatic studies to understand kinase specificity and mechanism.
• Neuroscience Research: Probing cAMP's function in neuronal signaling, synaptic plasticity, and memory formation.

Basic Information

Product Name	Sp-Adenosine 3',5'-Cyclic Monophosphothioate Triethylamine
CAS No.	93602-66-5
Molecular Formula	C18H31N6O5PS · C6H15N
Molecular Weight	Approx. 548.6 g/mol (free acid)
Synonyms	Sp-cAMPS triethylamine salt; Adenosine 3',5'-cyclic monophosphorothioate, Sp-isomer, triethylammonium salt; (Sp)-Adenosine cyclic 3',5'-(hydrogen phosphorothioate) triethylamine salt; cAMP-S, Sp-isomer; Sp-cyclic AMPS; Rp/Sp-cAMPS; Protein Kinase A Activator (Sp-isomer)
EINECS	Contact for details

Quality Control

Our Sp-Adenosine 3',5'-Cyclic Monophosphothioate Triethylamine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided to ensure it meets the stringent requirements for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.