Description

5-Iodo-2-Pyrimidinone-2'-Deoxyribose is a halogenated nucleoside derivative, a key building block in synthetic organic chemistry and pharmaceutical research. Its primary value lies in its role as a versatile intermediate for the synthesis of modified oligonucleotides and nucleoside analogs. This compound is essential for researchers and manufacturers in the fields of antiviral drug development, diagnostic probe synthesis, and medicinal chemistry, where precise molecular modifications are required.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Oligonucleotide Synthesis: Used in the preparation of iodine-labeled DNA probes for diagnostic and research applications.
• Medicinal Chemistry Research: Serves as a precursor for structure-activity relationship (SAR) studies and prodrug development.
• Bioconjugation: Acts as a handle for site-specific labeling and cross-linking in bioconjugate chemistry.
• Chemical Biology: Employed in the development of tools for studying nucleic acid interactions and enzyme mechanisms.
• Process Development: Used in scaling up routes for active pharmaceutical ingredients (APIs) containing modified nucleosides.

Basic Information

Product Name	5-Iodo-2-Pyrimidinone-2'-Deoxyribose
CAS No.	93265-81-7
Molecular Formula	C9H11IN2O5
Molecular Weight	354.10 g/mol
Synonyms	5-Iodo-2'-deoxyuridine; 5-Iodo-2'-deoxyuridine (5-I-dU); 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione; 5-Iododeoxyuridine; Idoxuridine impurity; 5-I-dUrd; 5-Iodo-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 5-Iodo-2-Pyrimidinone-2'-Deoxyribose is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.