Description

1-(4-Thio-β-D-Ribofuranosyl)Cytosine is a modified nucleoside analog where the oxygen atom in the ribose sugar ring is replaced by sulfur at the 4' position. This structural modification is of significant interest in medicinal chemistry and biochemistry for its potential to alter biological activity and metabolic stability. It serves as a key intermediate and research tool for scientists developing novel antiviral and anticancer therapeutics. This compound is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on nucleoside chemistry.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Biochemical Research: Used as a probe to study enzyme mechanisms, particularly those involving ribonucleotide metabolism and DNA/RNA polymerases.
• Antiviral Agent Development: Serves as a precursor for thionucleosides being investigated for activity against a range of viral targets.
• Anticancer Research: Explored for its potential to be incorporated into oligonucleotides or used directly to inhibit cancer cell proliferation.
• Enzyme Inhibition Studies: Acts as a substrate analog to investigate the function and inhibition of thymidylate synthase and other key enzymes.
• Fine Chemical Synthesis: Employed in custom synthesis and the production of specialized nucleotides for diagnostic and research markets.

Basic Information

Item	Details
Product Name	1-(4-Thio-β-D-Ribofuranosyl)Cytosine
CAS No.	93080-09-2
Molecular Formula	C9H13N3O4S
Molecular Weight	259.28 g/mol
Synonyms	4'-Thiocytidine; 4'-Thio-β-D-ribofuranosylcytosine; 1-(4-Thio-β-D-ribofuranosyl)cytosine; 4'-Thio-Cytidine; NSC 401005; 4'-S-Cytidine; β-4'-Thiocytidine
EINECS	Contact for details

Quality Control

Our 1-(4-Thio-β-D-Ribofuranosyl)Cytosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of the pharmaceutical and biotechnology industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.