Description

3-Methyl-2'-Deoxyguanosine is a modified nucleoside analog of deoxyguanosine, featuring a methyl group at the 3-position of the purine ring. This specific structural modification makes it a valuable biochemical tool and a critical intermediate in nucleic acid research and pharmaceutical development. It is essential for researchers and manufacturers in the fields of antiviral drug discovery, oncology research, and epigenetics, where precise nucleoside analogs are required to study DNA damage, repair mechanisms, and therapeutic agent synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a substrate or standard in enzymatic studies related to DNA methylation, repair pathways, and mutagenesis.
• Proteomics & Genomics: Serves as a modified component in oligonucleotide synthesis for probing nucleic acid structure and function.
• Diagnostic Reagent Development: Employed in the creation of assays and kits for detecting specific DNA lesions or epigenetic markers.
• Reference Standard: High-purity material for use as a chromatographic reference standard in quality control laboratories.
• Academic Research: Fundamental tool in university and institutional labs for studying the biological impact of alkylated DNA bases.

Basic Information

Product Name	3-Methyl-2'-Deoxyguanosine
CAS No.	92754-66-0
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	3-Methyl-2'-deoxyguanosine; 3-Methyl-deoxyguanosine; 2'-Deoxy-3-methylguanosine; 3-Methyl-dG; N3-Methyl-2'-deoxyguanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3-methyl-3,9-dihydro-1H-purin-6-one; 3-Me-dG; O6-Methyl-2'-deoxyguanosine (isomer distinction)
EINECS	Contact for details

Quality Control

Every batch of our 3-Methyl-2'-Deoxyguanosine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the stringent requirements for research and cGMP-grade intermediate applications. A Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identification, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.