Description

2-Azetidinecarbonyl Chloride, 1,4-Dimethyl-, trans- (9Ci) is a specialized heterocyclic building block featuring a reactive acid chloride functional group on a constrained azetidine ring. This compound matters for its role as a key intermediate in the synthesis of complex pharmaceutical molecules and advanced materials, enabling the introduction of the unique, rigid trans-dimethylazetidine moiety. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel bioactive compounds and functional polymers.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting neurological disorders and metabolic diseases.
• Agrochemical Research: Used in the development of novel herbicides and fungicides, where the azetidine ring can contribute to unique biological activity and environmental stability.
• Peptidomimetics & Bioisosteres: Serves as a constrained scaffold to replace peptide bonds or other flexible moieties in drug design, improving metabolic stability and receptor binding affinity.
• Polymer Chemistry: Employed as a monomer or cross-linking agent for creating specialty polymers with tailored thermal and mechanical properties.
• Ligand Synthesis: Utilized in the preparation of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Acts as a reactive handle for labeling proteins or other biomolecules to study biological pathways.

Basic Information

Product Name	2-Azetidinecarbonyl Chloride, 1,4-Dimethyl-, trans- (9Ci)
CAS No.	92735-68-7
Molecular Formula	C6H10ClNO
Molecular Weight	147.60 g/mol
Synonyms	trans-1,4-Dimethylazetidine-2-carbonyl chloride; (2R,4S)-1,4-Dimethylazetidine-2-carbonyl chloride; (2S,4R)-1,4-Dimethylazetidine-2-carbonyl chloride; 1,4-Dimethyl-2-azetidinecarbonyl chloride, trans-; trans-2-(Chlorocarbonyl)-1,4-dimethylazetidine; Azetidine-2-carbonyl chloride, 1,4-dimethyl-, trans-
EINECS	Contact for details

Quality Control

Our 2-Azetidinecarbonyl Chloride, 1,4-Dimethyl-, trans- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.