Description

2-Azetidinecarbonylchloride,1-(1,1-Dimethylethyl)-4-Methyl-,cis-(9Ci) is a high-purity, cis-configured azetidine derivative, specifically engineered as a critical building block for advanced organic synthesis. Its value lies in providing a protected, reactive scaffold that enables the precise construction of complex nitrogen-containing heterocycles, which are pivotal in modern pharmaceutical and agrochemical discovery. This compound is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require reliable, high-quality intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Agrochemical Research: Used in constructing proprietary heterocyclic scaffolds for next-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profiles.
• Peptidomimetics & PROTACs: The azetidine core is valuable for creating conformationally constrained peptide mimics and as a linker component in Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Material Science: Employed in the development of specialty polymers and functionalized surfaces where the introduction of a rigid, nitrogen-containing heterocycle modifies material properties.
• Chemical Biology Probes: Acts as a versatile handle for labeling and modifying biomolecules to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D programs.

Basic Information

Product Name	2-Azetidinecarbonylchloride,1-(1,1-Dimethylethyl)-4-Methyl-,cis-(9Ci)
CAS No.	92735-65-4
Molecular Formula	C9H16ClNO
Molecular Weight	189.68 g/mol
Synonyms	1-(tert-Butyl)-4-methyl-2-azetidinecarbonyl chloride, cis-; cis-1-tert-Butyl-4-methylazetidine-2-carbonyl chloride; 1-tert-Butyl-4-methylazetidine-2-carbonyl chloride (cis-); 2-Azetidinecarbonyl chloride, 1-(1,1-dimethylethyl)-4-methyl-, cis-; cis-1-(tert-Butyl)-4-methylazetidine-2-carboxylic acid chloride; Azetidine-2-carbonyl chloride derivative; tert-Butyl-methylazetidine carbonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Azetidinecarbonylchloride,1-(1,1-Dimethylethyl)-4-Methyl-,cis-(9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the exacting standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, isomer content, and impurity profiles are provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (cis-)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.