Description

1-Chloro-2-Methylpropyl Chloroformate is a versatile and reactive chloroformate ester used as a key reagent in organic synthesis. Its primary value lies in its ability to act as a protecting group or an activating agent for carboxylic acids, facilitating the formation of amides, esters, and carbonates under mild conditions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries developing active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Employed as a coupling agent in the preparation of active pharmaceutical ingredients (APIs) and prodrugs.
• Peptide Chemistry: Used for the temporary protection of amino groups or as an activating reagent in peptide bond formation.
• Agrochemical Production: Serves as a building block in the synthesis of herbicides, fungicides, and plant growth regulators.
• Polymer Modification: Acts as a functional monomer or cross-linking agent in the production of specialty polymers and resins.
• Chemical Derivatization: Utilized for the derivatization of analytes in chromatography to improve detection or separation.
• Laboratory Reagent: A valuable tool in research laboratories for introducing the chloroformate functional group into target molecules.

Basic Information

Product Name	1-Chloro-2-Methylpropyl Chloroformate
CAS No.	92600-11-8
Molecular Formula	C5H8Cl2O2
Molecular Weight	171.02 g/mol
Synonyms	Isobutyl Chloroformate, Chloroformic Acid; 1-Chloro-2-methylpropyl Ester; Chloroformic Acid Isobutyl Ester; 2-Methyl-1-chloropropyl Chloroformate; Isobutyl Chlorocarbonate; 1-Chloro-2-methylpropyl Carbonochloridate; (1-Chloro-2-methylpropoxy)carbonyl Chloride
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-Methylpropyl Chloroformate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for synthetic applications. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to maximize stability. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.18 g/cm³
Refractive Index (n20D)	~1.420

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.