Description

Beta,γ-Methylene-7,8-Dihydroneopterin 3'-Triphosphate is a chemically modified nucleotide analog of the key folate biosynthesis intermediate, 7,8-dihydroneopterin triphosphate. This compound is of significant value as a potent and specific inhibitor of the enzyme GTP cyclohydrolase I, a critical target in biochemical research and therapeutic development. It is primarily utilized by research scientists and pharmaceutical developers in enzymology studies, metabolic pathway analysis, and the investigation of conditions related to folate and neurotransmitter synthesis.

Application

• Enzymology Research: As a specific inhibitor for mechanistic studies of GTP cyclohydrolase I (GCH1) activity and regulation.
• Biochemical Pathway Analysis: Used to block the de novo biosynthesis of tetrahydrobiopterin (BH4) in cell culture and in vitro systems to study downstream effects.
• Pharmaceutical Target Validation: Serves as a tool compound in drug discovery programs targeting inflammatory, cardiovascular, and neurological disorders linked to GCH1/BH4 pathways.
• Reference Standard: Employed as a high-purity analytical standard in HPLC, LC-MS, or NMR for method development and quality control in related research.
• Metabolic Studies: Facilitates research into nitric oxide synthase (NOS) function, monoamine neurotransmitter synthesis, and immune response modulation.

Basic Information

Product Name	Beta,γ-Methylene-7,8-Dihydroneopterin 3'-Triphosphate
CAS No.	92587-05-8
Molecular Formula	C11H17N5O13P3
Molecular Weight	568.20 g/mol
Synonyms	7,8-Dihydroneopterin 3'-triphosphate beta,γ-methylene analog; GTP Cyclohydrolase I Inhibitor; MDHP; Beta,γ-Methylene-DHNP triphosphate; 2-Amino-6-[(1S,2R)-1,2-dihydroxy-3-(hydroxy-{[hydroxy({[hydroxy(phosphonooxy)phosphoryl]oxy})phosphoryl]oxy}propyl]-4(3H)-pteridinone; NSC 613111; (1S,2R)-1-(2-Amino-4-oxo-3,4-dihydro-7-pteridinyl)-2-hydroxy-3-[(phosphonooxy)hydroxyphosphoryl]oxypropyl dihydrogen phosphate
EINECS	Contact for details

Quality Control

Our Beta,γ-Methylene-7,8-Dihydroneopterin 3'-Triphosphate is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for advanced research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by HPLC, NMR, and mass spectrometry. We adhere to ISO 9001 quality management principles to guarantee reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.