Description

2'-Chloro-2'-Deoxyuridine 5'-Phosphate is a modified nucleoside monophosphate analog of deoxyuridine, where a chlorine atom replaces the hydroxyl group at the 2' position of the ribose sugar. This specific structural modification makes it a valuable biochemical tool and a key intermediate in the research and development of antiviral and anticancer agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in nucleotide chemistry, enzymology studies, and the synthesis of novel therapeutic compounds.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly with thymidine kinase and other nucleotide-metabolizing enzymes.
• Antiviral Drug Development: Serves as a critical synthetic intermediate in the research of nucleoside analog prodrugs targeting viral polymerases.
• Oncology Research: Investigated as a precursor for compounds designed to interfere with DNA synthesis in rapidly dividing cancer cells.
• Nucleotide Chemistry: Employed in organic synthesis to create more complex nucleotide structures or labeled analogs for diagnostic purposes.
• Molecular Biology: Potential use in studying DNA repair mechanisms and cell cycle regulation.

Basic Information

Product Name	2'-Chloro-2'-Deoxyuridine 5'-Phosphate
CAS No.	92544-26-8
Molecular Formula	C9H12ClN2O9P
Molecular Weight	382.63 g/mol
Synonyms	2'-Chloro-2'-deoxyuridine 5'-monophosphate; 2'-Cl-2'-dUMP; 5'-UMP-2'-Cl; 2'-Chloro-2'-deoxyuridylic acid; 2'-Chloro-dUMP; 2'-Chloro-2'-deoxy-5'-UMP; 2'-Chloro-5'-UMP; 2'-Cl-dUMP
EINECS	Contact for details

Quality Control

Our 2'-Chloro-2'-Deoxyuridine 5'-Phosphate is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.