Description

Cyclohexanecarbonyl Chloride, 5-Chloro-2-Methyl-, (1Alpha,2Beta,5Alpha)- (9Ci) is a specialized chiral organic intermediate featuring a reactive acid chloride functional group. This compound matters for its role as a key building block in the synthesis of complex, stereochemically defined molecules, enabling the introduction of a substituted cyclohexane moiety. It is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting the central nervous system or with specific steric requirements.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the chiral, substituted cyclohexane structure imparts specific biological activity.
• Organic Synthesis Reagent: Serves as an acylating agent in research laboratories for the preparation of amides, esters, and ketones under mild conditions.
• Ligand and Catalyst Development: Employed in the construction of chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: A potential monomer or modifier for creating polymers with unique thermal or mechanical properties derived from the cycloaliphatic structure.

Basic Information

Product Name	Cyclohexanecarbonyl Chloride, 5-Chloro-2-Methyl-, (1Alpha,2Beta,5Alpha)- (9Ci)
CAS No.	92284-42-9
Molecular Formula	C8H12Cl2O
Molecular Weight	195.09 g/mol
Synonyms	(1R,2S,5R)-5-Chloro-2-methylcyclohexanecarbonyl chloride; (1α,2β,5α)-5-Chloro-2-methylcyclohexanecarboxylic acid chloride; 5-Chloro-2-methylcyclohexanecarbonyl chloride (stereoisomer); 5-Chloro-O-toluoyl chloride (related); Cyclohexanecarboxylic acid, 5-chloro-2-methyl-, chloride, (1R,2S,5R)-; Chiral Cyclohexanoyl Chloride Derivative
EINECS	Contact for details

Quality Control

Our production of Cyclohexanecarbonyl Chloride, 5-Chloro-2-Methyl-, (1Alpha,2Beta,5Alpha)- (9Ci) adheres to strict quality protocols. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure high chemical and isomeric purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.