Description

2-Amino-6-Allylthio-9-(β-D-Ribofuranosyl)-9H-Purine is a specialized nucleoside analog with a modified purine base, distinguished by its allylthio substitution at the 6-position. This structural modification is critical for its role as a key synthetic intermediate and research chemical in advanced pharmaceutical development. It is primarily utilized by research institutions and manufacturers in the life sciences sector focusing on antiviral and anticancer drug discovery, as well as in biochemical research for studying enzyme mechanisms and nucleic acid chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel nucleoside-based antiviral and anticancer agents.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for purine-metabolizing enzymes and polymerases.
• Proteomics & Genomics: Serves as a modified nucleoside for probing nucleic acid structure and function, and in the development of diagnostic assays.
• Academic Research: Employed in university and institutional labs for fundamental studies in medicinal chemistry and chemical biology.
• Process Development: Used by CROs and CDMOs for scaling up synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-Amino-6-Allylthio-9-(β-D-Ribofuranosyl)-9H-Purine
CAS No.	92104-54-6
Molecular Formula	C13H17N5O4S
Molecular Weight	339.37 g/mol
Synonyms	6-Allylthio-9-β-D-ribofuranosyl-9H-purin-2-amine; 2-Amino-6-(allylthio)-9-β-D-ribofuranosyl-9H-purine; 6-Allylmercapto-9-(β-D-ribofuranosyl)purin-2-ylamine; 9-β-D-Ribofuranosyl-6-allylthiopurin-2-amine; NSC 375149; 2-Amino-6-allylsulfanyl-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purine
EINECS	Contact for details

Quality Control

Our 2-Amino-6-Allylthio-9-(β-D-Ribofuranosyl)-9H-Purine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with detailed specifications to ensure traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.