Description

Kazusamycin A from Streptomyces sp. is a potent ansamycin-class antibiotic and antitumor agent derived from a specific Streptomyces species. This compound is of significant interest in pharmaceutical research and development due to its unique mechanism of action and biological activity. It is primarily utilized by researchers in the fields of oncology, microbiology, and medicinal chemistry for drug discovery and biochemical studies.

Application

• Anticancer Research: Investigated for its cytotoxic activity against various cancer cell lines in preclinical studies.
• Antibiotic Mechanism Studies: Used as a biochemical tool to study bacterial RNA polymerase inhibition and antibiotic resistance.
• Medicinal Chemistry: Serves as a lead compound or reference standard for the synthesis and evaluation of novel ansamycin derivatives.
• Pharmacological Screening: Employed in high-throughput screening assays to identify new therapeutic targets and pathways.
• Academic & Institutional Research: Used in university and institutional labs for fundamental research in natural product chemistry and microbiology.
• Biopharmaceutical Development: Acts as a critical reference material in the quality control and development of related biologic or small-molecule therapeutics.

Basic Information

Product Name	Kazusamycin A from Streptomyces sp.
CAS No.	92090-94-3
Molecular Formula	C34H44N2O9
Molecular Weight	624.73 g/mol
Synonyms	Kazusamycin A; Antibiotic KA 6643; KA 6643; Ansamycin KA 6643; (3E,5E,7E,9E,11E,13E,15E)-16-[(2R,3S,4S,5S,6R)-4-(Dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-5-ethyl-4,6,8,10,12,14,16-heptamethyl-17-(2-methyl-1,3-oxazol-5-yl)heptadeca-3,5,7,9,11,13,15-heptaen-2-one
EINECS	Contact for details

Quality Control

Our Kazusamycin A is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and potency. We support compliance with relevant standards for research-grade materials, and specifications can be provided to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Biological Activity	Assayed; Data on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.