Description

1-Aziridinecarboxylic Acid, 2-(Trimethylsilyl)-, Methyl Ester is a specialized organosilicon-protected aziridine derivative, a crucial building block in advanced organic synthesis. Its value lies in providing a masked, reactive aziridine functionality that enables the controlled introduction of nitrogen-containing three-membered rings into complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for its role in synthesizing amino acid analogs and constrained peptidomimetics.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially protease inhibitors and other biologically active molecules containing aziridine or modified amino acid motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that incorporate nitrogen heterocycles for enhanced activity.
• Peptidomimetic Research: Serves as a constrained scaffold for creating peptide analogs with improved metabolic stability and bioavailability in medicinal chemistry.
• Polymer Science: Acts as a monomer or cross-linking agent in the development of specialty polymers with unique chemical and physical properties.
• Material Science: Employed in surface modification and the creation of functionalized materials where the silyl group allows for specific deposition or reactivity.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis, particularly in studies involving ring-opening reactions and stereoselective transformations.

Basic Information

Product Name	1-Aziridinecarboxylic Acid, 2-(Trimethylsilyl)-, Methyl Ester
CAS No.	91936-00-4
Molecular Formula	C8H17NO2Si
Molecular Weight	187.31 g/mol
Synonyms	Methyl 2-(Trimethylsilyl)aziridine-1-carboxylate; 2-(Trimethylsilyl)aziridine-1-carboxylic acid methyl ester; Aziridine-1-carboxylic acid, 2-(trimethylsilyl)-, methyl ester; 1-Carbomethoxy-2-trimethylsilylaziridine; Methyl N-Carboxy-2-trimethylsilylaziridine; 2-TMS-aziridine-1-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 1-Aziridinecarboxylic Acid, 2-(Trimethylsilyl)-, Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.