Description

(R)-Bifonazole CAS NO 91487-85-3 is the single enantiomer of the broad-spectrum antifungal agent Bifonazole, offering a high degree of stereochemical purity for advanced pharmaceutical research and development. This specific chiral form is critical for studying structure-activity relationships, developing more potent or selective antifungal therapies, and meeting stringent regulatory requirements for enantiopure active pharmaceutical ingredients (APIs). It is an essential building block for medicinal chemists, process development scientists, and manufacturers in the pharmaceutical and fine chemical industries focused on innovative antifungal solutions.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel, enantiomerically pure antifungal drugs.
• Research & Development: Used in biochemical and pharmacological studies to investigate the specific biological activity and metabolic pathways of the (R)-enantiomer.
• Reference Standard: Employed as a high-purity analytical standard for method development, validation, and quality control in API manufacturing.
• Asymmetric Synthesis: Acts as a model compound or intermediate in developing and optimizing chiral synthesis routes.
• Mechanism of Action Studies: Utilized to elucidate the precise interaction between the enantiopure form and its biological target, such as lanosterol 14α-demethylase.

Basic Information

Product Name	(R)-Bifonazole
CAS No.	91487-85-3
Molecular Formula	C22H18N2
Molecular Weight	310.40 g/mol
Synonyms	(R)-1-[(1,1'-Biphenyl)-4-ylphenylmethyl]-1H-imidazole; (R)-α-(4-Biphenylyl)benzylimidazole; (R)-Bifonazol; (R)-Mycospor; (R)-Bay h 4502; (R)-Enantiomer of Bifonazole; (R)-2-[(4-Biphenylyl)phenylmethyl]imidazole
EINECS	Contact for details

Quality Control

Our (R)-Bifonazole is manufactured under strict quality management systems to ensure high enantiomeric purity and chemical integrity. Each batch is characterized and tested using advanced analytical techniques, including chiral HPLC, to confirm identity, purity, and enantiomeric excess (e.e.). A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.