Description

2-Hexynyladenosine is a synthetic nucleoside derivative, specifically an adenosine analog modified with a hexynyl group at the 2-position. This structural modification is of significant interest for its potential to modulate biological pathways, particularly in the field of medicinal chemistry and biochemical research. It serves as a valuable building block and research chemical for scientists developing novel therapeutic agents, enzyme inhibitors, and molecular probes targeting adenosine receptors and related signaling networks.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel adenosine receptor agonists or antagonists.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the function of kinases, phosphorylases, and other adenosine-metabolizing enzymes.
• Medicinal Chemistry: Employed as a core scaffold for structure-activity relationship (SAR) studies aimed at creating new drug candidates for cardiovascular, inflammatory, or neurological disorders.
• Molecular Probe Development: Acts as a starting material for synthesizing labeled compounds (e.g., fluorescent or radioactive tags) used in cellular imaging and binding assays.
• Nucleic Acid Chemistry: Potential use in the synthesis of modified oligonucleotides for antisense or aptamer technologies.

Basic Information

Product Name	2-Hexynyladenosine
CAS No.	90596-73-9
Molecular Formula	C₁₇H₂₃N₅O₄
Molecular Weight	361.40 g/mol
Synonyms	2-(1-Hexyn-1-yl)adenosine; N⁶-(1-Hexyn-1-yl)adenosine; Adenosine, 2-(1-hexynyl)-; 2-Hex-1-ynyladenosine; 9-β-D-Ribofuranosyl-2-(1-hexyn-1-yl)adenine; 2-(Hex-1-yn-1-yl)adenosine
EINECS	Contact for details

Quality Control

Our 2-Hexynyladenosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.