Description

1,3-Dioxolane-4-Carbonyl Chloride, 2,2-Dimethyl- is a high-purity, reactive acyl chloride derivative featuring a protected acetal functional group. This compound is a critical advanced pharmaceutical intermediate (API) and a versatile building block for synthesizing complex organic molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the introduction of functionalized carbonyl moieties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring chiral or protected aldehyde functionalities.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators.
• Peptide Chemistry: Serves as a coupling agent or protecting group reagent in the synthesis of modified peptides and peptidomimetics.
• Material Science: Monomer or cross-linking agent for creating specialized polymers with acetal linkages for controlled degradation or specific solubility profiles.
• Organic Synthesis: Versatile reagent for acylations and as a precursor to aldehydes under mild deprotection conditions in multi-step synthetic routes.
• Ligand and Catalyst Development: Intermediate for synthesizing novel chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	1,3-Dioxolane-4-Carbonyl Chloride, 2,2-Dimethyl-
CAS No.	90493-96-2
Molecular Formula	C6H9ClO3
Molecular Weight	164.59 g/mol
Synonyms	2,2-Dimethyl-1,3-dioxolane-4-carbonyl chloride; 4-(Chlorocarbonyl)-2,2-dimethyl-1,3-dioxolane; (2,2-Dimethyl-1,3-dioxolan-4-yl)carbonyl chloride; Glyceraldehyde acetonide carbonyl chloride; D-Glyceraldehyde acetonide carbonyl chloride; L-Glyceraldehyde acetonide carbonyl chloride; (R)-2,2-Dimethyl-1,3-dioxolane-4-carbonyl chloride; (S)-2,2-Dimethyl-1,3-dioxolane-4-carbonyl chloride
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolane-4-Carbonyl Chloride, 2,2-Dimethyl- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.