Description

7-Methyl-7-Deaza-2’-Deoxyguanosine is a chemically modified nucleoside analog of deoxyguanosine, featuring a methyl group at the 7-position of a 7-deazapurine ring system. This structural modification is crucial for its role as a building block in oligonucleotide synthesis, particularly for creating probes and primers with enhanced stability and specific binding properties. It is primarily utilized by researchers and manufacturers in the fields of molecular biology, diagnostic assay development, and pharmaceutical research.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of modified DNA and RNA strands.
• Molecular Probes: Used to create fluorescently labeled or otherwise tagged probes for techniques like FISH (Fluorescence In Situ Hybridization) and microarray analysis.
• PCR and Sequencing: Incorporated into primers to improve specificity, reduce primer-dimer formation, or alter melting temperatures.
• Antisense and siRNA Research: Serves as a modified base in therapeutic oligonucleotides to enhance nuclease resistance and target affinity.
• Structural Studies: Employed in X-ray crystallography and NMR studies to investigate nucleic acid structure and protein-nucleic acid interactions.
• Diagnostic Kit Manufacturing: A critical raw material in the production of kits for genetic testing, pathogen detection, and companion diagnostics.

Basic Information

Product Name	7-Methyl-7-Deaza-2’-Deoxyguanosine
CAS No.	90358-21-7
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	7-Methyl-7-deaza-2'-deoxyguanosine; 7-Methyl-7-deaza-dG; 2'-Deoxy-7-methyl-7-deazaguanosine; 7-Methylpyrazolo[3,4-d]pyrimidine-2'-deoxyriboside; c7-Methyl-dG; 7-Methyl-2'-deoxy-7-deazaguanosine; 4-Amino-7-methyl-5H-pyrrolo[3,2-d]pyrimidin-7-ium-2'-deoxyriboside
EINECS	Contact for details

Quality Control

Our 7-Methyl-7-Deaza-2’-Deoxyguanosine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for sensitive life science applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.