Description

Clotrimazole-Hydrocortisone is a combination active pharmaceutical ingredient (API) that merges the potent antifungal properties of clotrimazole with the anti-inflammatory action of hydrocortisone. This synergistic compound is critical for developing effective topical treatments that address both the infection and the associated inflammatory response. It is primarily required by pharmaceutical manufacturers for the production of creams, ointments, and lotions used in dermatology to treat conditions like athlete's foot, jock itch, and other cutaneous fungal infections.

Application

• Topical Antifungal Creams & Ointments: Primary use in formulations for treating tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm).
• Dermatological Preparations: Used in medicated lotions and powders to combat skin yeast infections and reduce associated redness, swelling, and itching.
• Veterinary Pharmaceuticals: Incorporated into topical treatments for fungal skin infections in animals.
• Over-the-Counter (OTC) Medicated Products: A key ingredient in consumer healthcare products for skin care and fungal infection treatment.
• Prescription-Strength Formulations: Serves as the active component in higher-dose prescription topical medications.
• Research & Development: Used in pharmaceutical R&D for developing new combination topical therapies and studying drug delivery systems.

Basic Information

Item	Details
Product Name	Clotrimazole-Hydrocortisone
CAS No.	90155-19-4
Molecular Formula	C26H30Cl2N2O6 (Clotrimazole: C22H17ClN2; Hydrocortisone: C21H30O5)
Molecular Weight	525.43 g/mol
Synonyms	Clotrimazole and Hydrocortisone; Hydrocortisone Acetate and Clotrimazole; 1-[(2-Chlorophenyl)(diphenyl)methyl]-1H-imidazole combined with 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione; Canesten-HC; Lotriderm; Clotrasone; Hydrocortisone/Clotrimazole; Antifungal-Antiinflammatory Combination API
EINECS	Contact for details

Quality Control

Our Clotrimazole-Hydrocortisone is manufactured under strict quality systems. Each batch is tested to ensure it meets stringent specifications for identity, potency, purity, and related substances, aligning with pharmacopeial standards. A comprehensive Certificate of Analysis (COA) documenting all test results is provided with every shipment to guarantee traceability and compliance for our pharmaceutical partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (Clotrimazole)	47.0% - 53.0%
Assay (Hydrocortisone)	47.0% - 53.0%
Related Substances (HPLC)	NMT 2.0% total impurities
Water Content (KF)	NMT 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	NMT 20 ppm
Microbial Enumeration	Complies with Ph. Eur. 2.6.12/ USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.