Description

Hydroxy-[[Hydroxy-[[(2R,3S,5R)-3-Hydroxy-5-(5-Methyl-2,4-Dioxo-Pyrimidin-1-Yl)Oxolan-2-Yl]Methoxy]Phosphoryl]Methyl]Phosphoryl]Methylphosphonic Acid is a high-purity, chemically defined nucleotide analog with significant research and pharmaceutical development potential. This compound matters as a critical building block for advanced oligonucleotide synthesis, enabling the development of novel therapeutics and diagnostic tools. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on antisense technology, siRNA, and other nucleic acid-based applications.

Application

• Pharmaceutical Intermediate: Serves as a key raw material in the synthesis of modified oligonucleotides for therapeutic applications.
• Antisense Oligonucleotide (ASO) Development: Used in research and production of ASOs targeting specific mRNA sequences.
• siRNA and miRNA Synthesis: Acts as a phosphonate-modified nucleotide precursor for RNA interference (RNAi) therapeutics.
• Diagnostic Probe Development: Employed in creating labeled probes for genetic testing and molecular diagnostics.
• Biochemical Research: Utilized in studies investigating nucleic acid structure, function, and enzyme interactions.
• Nucleotide Analog Library Synthesis: A valuable component for building diverse libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	Hydroxy-[[Hydroxy-[[(2R,3S,5R)-3-Hydroxy-5-(5-Methyl-2,4-Dioxo-Pyrimidin-1-Yl)Oxolan-2-Yl]Methoxy]Phosphoryl]Methyl]Phosphoryl]Methylphosphonic Acid
CAS No.	90094-77-2
Molecular Formula	C11H19N2O13P3
Molecular Weight	504.19 g/mol
Synonyms	1-[(2R,3S,5R)-3-Hydroxy-5-[[hydroxy([hydroxy(methylphosphonato)phosphoryl]methoxy)phosphoryl]methoxy]oxolan-2-yl]-5-methylpyrimidine-2,4-dione; Thymidine 5'-[P1-(methylphosphonic acid),P3-dihydrogen] triphosphate; Methylenediphosphonate thymidine derivative; 5'-O-[[[Hydroxy(methylphosphono)phosphinyl]oxy]methylphosphinyl]thymidine; Nucleotide methylenediphosphonate analog; dTMP-CH2-PP; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this nucleotide analog adheres to strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; desiccants are recommended for long-term storage. Keep container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.