Description

3-(3-Oxoprop-2-Enyl)Thymidine is a chemically modified nucleoside derivative, serving as a crucial intermediate in advanced organic synthesis and pharmaceutical research. This compound is valued for its reactive α,β-unsaturated ketone moiety, which enables its use in conjugation and cross-linking reactions. It is primarily utilized by researchers and manufacturers in the fields of medicinal chemistry, oligonucleotide synthesis, and the development of prodrugs and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Bioconjugation Chemistry: Used to create covalent linkages with proteins, peptides, or other biomolecules via Michael addition or other reactions.
• Oligonucleotide Modification: Enables the site-specific labeling or functionalization of DNA/RNA strands for diagnostic and research applications.
• Prodrug Development: Serves as a precursor in designing targeted prodrug systems for improved drug delivery and efficacy.
• Chemical Biology Research: Employed as a tool compound to study enzyme mechanisms or to create activity-based probes.
• Material Science: Potential use in creating functionalized polymers or surfaces with bioactive nucleoside components.

Basic Information

Product Name	3-(3-Oxoprop-2-Enyl)Thymidine
CAS No.	90029-85-9
Molecular Formula	C13H16N2O6
Molecular Weight	296.28 g/mol
Synonyms	3-[3-Oxoprop-2-en-1-yl]thymidine; 3-(3-Oxo-2-propen-1-yl)thymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-3-[(E)-3-oxoprop-1-enyl]pyrimidine-2,4-dione; Thymidine, 3-(3-oxo-2-propenyl)-; 3-O-(3-Oxoprop-2-enyl)thymidine; 3-O-(3-Oxoallyl)thymidine; 3-O-(3-Oxo-2-propenyl)thymidine
EINECS	Contact for details

Quality Control

Our 3-(3-Oxoprop-2-Enyl)Thymidine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.