Description

Tocofersolan is a water-soluble derivative of Vitamin E, specifically d-α-tocopheryl polyethylene glycol succinate (TPGS). This compound is essential for formulating stable, bioavailable supplements and pharmaceutical products where the lipophilic nature of standard Vitamin E presents a challenge. It is a critical ingredient for manufacturers in the pharmaceutical, nutraceutical, and specialty food industries seeking to enhance the solubility, absorption, and stability of their formulations.

Application

• Pharmaceutical Solubilizer & Bioavailability Enhancer: Widely used as a non-ionic surfactant and emulsifier to improve the solubility and oral absorption of poorly water-soluble active pharmaceutical ingredients (APIs).
• Vitamin E Supplementation in Liquid Dosage Forms: Enables the formulation of clear, stable aqueous solutions, syrups, and softgels for Vitamin E delivery, overcoming oil-based formulation limitations.
• Nutraceutical & Dietary Supplement Formulations: A key component in multivitamin liquids, energy drinks, and specialized nutritional products requiring water-soluble Vitamin E activity.
• Excipient in Drug Delivery Systems: Employed in micellar drug delivery, self-emulsifying drug delivery systems (SEDDS), and as a P-glycoprotein inhibitor to potentially enhance drug efficacy.
• Cosmetic & Personal Care Stabilizer: Used in high-end skincare and haircare products for its antioxidant properties and to stabilize other sensitive active ingredients in aqueous bases.
• Animal Feed & Veterinary Applications: Incorporated into liquid feed supplements and veterinary medications to ensure adequate Vitamin E intake and improved drug bioavailability.

Basic Information

Product Name	Tocofersolan
CAS No.	9002-96-4
Molecular Formula	C33O5H54(CH2CH2O)nH
Molecular Weight	Approx. 1513 (for n=23)
Synonyms	d-α-Tocopheryl Polyethylene Glycol Succinate; TPGS; Vitamin E TPGS; Tocophersolan; Polyethylene Glycol 1000 Succinate d-α-Tocopheryl Ester; Tocofersolum; PEG-1000 Vitamin E Succinate; Soluble Vitamin E
EINECS	Contact for details

Quality Control

Our Tocofersolan is manufactured and tested to meet stringent quality standards suitable for pharmaceutical and nutraceutical applications. We ensure compliance with relevant pharmacopoeial monographs where applicable. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, assay, and critical physical-chemical parameters. Certificates of GMP compliance and REACH registration are available to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent caking and degradation. For long-term storage, consider using desiccants and maintaining an inert atmosphere to minimize oxidation.

Specification

Item	Specification
Appearance	White to off-white waxy solid
Identification (IR)	Conforms
Assay (Vitamin E Content)	Min. 260 mg/g
pH (5% Solution)	4.5 - 7.0
Water Content	Max. 1.0%
Heavy Metals (as Pb)	Max. 10 ppm
Residual Solvents	Complies with ICH Q3C
Polyethylene Glycol (PEG)	Contact for details
Average Molecular Weight (n)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.